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total synthesis is super fun.... lol.
I don't think it is difficult to find a job if you are doing total systhesis in the US. As long as you have one publication, it will become easier.
I always respect the total sythesis major people. It is said in chemistyr that once you can do total sysnthesis, you can do everything. But I don't think it is easy to get an offer in this area, even in the 2nd tier school.
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