寄托家园留学论坛

标题: 生物材料~~Careers [打印本页]

作者: headhuanglan 时间: 2015-3-8 02:24:11 标题: 生物材料~~Careers

看了【人在美国之十一】 https://bbs.gter.net/thread-1808722-1-1.html
纯搞生物的同学。。。貌似跳到了生物材料的group求毕业。。。但生物材料真不知道是不是也是坑。。。。欢迎搞生材的前辈同辈说说就业出路专业情况什么的。。。。我还是很关心这个专业是坑么？？

下文转自：
http://sciencecareers.sciencemag.org/career_magazine/previous_issues/articles/2012_11_16/caredit.a1200127

Careers in Biomaterials Science—an Overview
One of the first career decisions Ralph Müller had to make after receiving his master’s degree in electrical engineering was whether to enter the movie industry or the medical field. He opted for the latter, developing imaging techniques to diagnose osteoporosis during his Ph.D. and then learning about clinical, biomechanical, and biological aspects of orthopedics during a postdoc at Harvard Medical School in Boston.

Müller's diverse training prepared him to enter the field of biomaterials science, and today he directs the Department of Health Sciences and Technology’s Institute for Biomechanics at the Swiss Federal Institute of Technology (ETH) Zurich, leading a multidisciplinary laboratory that studies the structure and mechanical behavior of natural and engineered tissues.

As biomaterials science has matured, it has taken on much more biological content, moving from an approach that emphasizes inertness to one that embraces biological activity. Biomaterials science is “a growing field. It’s an exciting field,” says Nicholas Peppas, who chairs the Department of Biomedical Engineering and leads the Laboratory of Biomaterials, Drug Delivery, Bionanotechnology and Molecular Recognition at the University of Texas, Austin. It is also a very challenging field, demanding increasingly broad—but also deep—training and an ever more interdisciplinary approach. “This kind of working together in these interdisciplinary groups is not always easy, and asks you to adapt,” Müller says.

An evolving field

Biomaterials

For biomaterials to move from the lab to the clinic, engineers, surgeons, and biologists must all tackle the challenges together. A special issue from Science. Also see the companion article from Science Careers.
Biomaterials are materials designed to be used in close contact with biological systems, tissues, and fluids and to serve a medical purpose—replacing a damaged organ, say, or treating a disease. Biomaterials are in wide use, including for titanium hip implants, microcapsules for drug delivery, and engineered skin.

But the characteristics of biomaterials have evolved over the field’s 50-plus years of existence. In the early days, biomaterials were expected to be inert, or at least biocompatible, to disturb the body as little as possible. The field has since shifted toward developing materials that interact with biological systems in a purposeful way. For example, researchers are developing “smart" biomaterials such as temperature-sensing hydrogels that can respond biologically to environmental conditions by changing their biomechanical or drug-releasing properties, says Seeram Ramakrishna, a professor of mechanical engineering and director of the Center for Nanofibers & Nanotechnology at the National University of Singapore.

Perhaps the field's biggest revolution was the introduction of stem cells, which ushered in the era of tissue engineering and regenerative medicine. A great deal of research is now going into developing scaffolds that can be used in vitro or in vivo to support and direct the growth of stem cells into differentiated cells, so they can restore a malfunctioning organ or injured tissue. Ramakrishna, for example, is engineering nanofibers for a physical structure with the right chemical, biological, and electrical cues to regenerate heart tissues.

CREDIT: Seeram Ramakrishna
Seeram Ramakrishna
A multidisciplinary field

The way that research is done has also been changing, with implications for those who wish to enter the field. As researchers have been pushing for biomaterials with greater activity and similarity to biological systems, they’ve had to work increasingly across disciplines. “This means, effectively, that scientists working in the biomaterials field have to have a good chemistry background, perhaps a good physics background, definitely good biochemistry and biology, and a good appreciation, of course, of materials science,” Peppas says.

The hardest part is bringing all of this together in vivo. “That is really the greatest challenge, because many scientists can come up with new materials for certain applications, … but if they don’t know how these materials are going to be placed in the body and interact with the cells, interact with biological fluids and so on, they have no appreciation of the total problem,” Peppas says.

At the end of the chain are doctors and their patients, Müller says—so those seeking to enter the field can benefit from putting themselves in the position of clinicians as they try to solve patients’ problems.

CREDIT: The University of Texas, Austin
Nicholas Peppas
Ways in

Because of the field's impressive breadth, the routes in are almost limitless. You can enter from materials science, chemical engineering, chemistry, physics, mechanical engineering, electrical engineering, biology, biotechnology, medicine, pharmacy—even mathematics and computer modeling.

The difficulty is that you need expertise in several of those disciplines, and learning that much science is hard. Biomaterials scientists have traditionally gained their multidisciplinary training by getting a first degree, a Ph.D., and a postdoc, each in a different field. Another increasingly common approach is to enter an integrated biomaterials program—but because such programs tend to cover a little bit of everything, there is a danger of superficiality. If scientists “start too early to specialize in biomaterials, there is a risk that they … would know all the possible applications but they will maybe not have the basis to be able to develop new ideas or new systems,” says Christine Dupont-Gillain, who leads the Nanostructured Surfaces for Cell Engineering group at the Institute of Condensed Matter and Nanosciences of the Université Catholique de Louvain in Belgium.

Whichever approach you take, you should strive to excel in a specific area, Müller says. “So if you came from engineering to this problem and we’re working at these interfaces of biology, medicine, and so forth, it’s best to stay on the engineering side … rather than to … start way below and go all the way up on biology or medicine.”

CREDIT: Christine Dupont-Gillain/Françoise Bouvy, Université Catholique de Louvain
Christine Dupont-Gillain
It is important to work in groups that are already active in the field of biomaterials science, Dupont-Gillain says. So make sure to choose a lab that is truly multidisciplinary or at least has some connections with other disciplines, the clinical environment, or people developing biomedical devices, she adds. Also look at the institution's broader scientific environment, because “you can benefit from help even from people that are not with the label ‘biomaterials,’ ” says Dupont-Gillain, who, as a bioengineer and physical chemist, collaborates with colleagues in surface science and cell biologists to develop biomimetic surfaces that can trigger desired cell behaviors.

Undergraduates interested in a biomaterials career should consider “spending a summer doing a medical internship, or spending some time in … a research and development environment of a company or in a government institute,” Peppas says. This will help to acquaint them with the field's objectives and demands. “The more experience they get early, … the better it will be for their future employment and for their future success.”

Peripheral skills

Not all the skills required in this field are scientific. One key trait of successful biomaterials scientists is an ability to span scientific cultures and speak a variety of scientific languages. It can be humbling. “You think you’re an expert and you don’t even know the very simple things and you have to ask all the time,” Müller says. “This is something that you have to overcome.”

You also need to be able to work in teams. “If you believe you are the only one that can bring the solution, I don’t think you will find anything, so you need to be very open-minded, have good communication abilities. … To gather people together is very important,” Dupont-Gillain says.

An understanding of research ethics is very important in biomaterials. Early-career scientists should take a course on medical ethics to gain an early appreciation of “some of the formidable difficulties in the biomaterials field,” Peppas says. Medical ethics covers the appropriate use of biomaterials in patients and for certain applications, but it also can help you deal with difficult situations, such as when you discover that a particular biomaterial you've spent several years developing "has some toxicity, or some adverse reaction with the tissue or with the body. One needs to be appreciative immediately of the fact that this has to be disclosed.”

CREDIT: Ralph Müller/Swiss Federal Institute of Technology (ETH) Zurich
Ralph Müller
It's important to maintain an awareness of the broader context of the research. The biomaterials field is different from medical engineering in that its devices are meant for use inside the body, so regulations are stringent and legal issues are considerable, Müller says. Cost is also a factor. “When we develop new biomaterials, we have to appreciate that … we have to come up with solutions that are cost-effective,” Peppas says. Some biomaterials scientists even have formal business education, like a master's degree in business administration.

Rewards and opportunities

Peppas believes that the "explosion in the field” brought about by the emergence of tissue engineering and regenerative medicine means increasing opportunities for young scientists. Currently, the majority of biomaterials jobs are in academia, but the private sector is showing signs of activity, with academic labs spinning out companies, pharmaceutical companies allying themselves to biomaterials companies, and traditional medical implant companies looking to replace their 50-year-old technology, Müller adds.

But Peppas expects the field's expansion to be limited eventually by constraints on healthcare costs. And Ramakrishna points out that rising enrollments in biomaterials training programs are already making the job search difficult, especially in industry. “The numbers of graduates that are coming out are enormous around the world. Now, all of them cannot find jobs in the same area,” Ramakrishna says.

Choosing a career in biomaterials is “risky, but you could be a part of something amazing,” Müller says. Beyond the excitement of working in a multidisciplinary and challenging field, biomaterials science offers the sense that your work is likely to directly benefit human health. “The biggest satisfaction of a scientist working in biomaterials, whether he is in the academic environment or … a government institute or in industry, is to see these materials used in patients," Peppas says.

作者: wang_come_on 时间: 2015-3-8 09:43:30

我个人的感觉是生物相关的方向工业界都不是很好找工作，因为这些产业都还不成熟。从学术的角度，生物材料也是一个面比较宽的方向，相对也比较容易上手

作者: HumanEmpire 时间: 2015-3-8 10:04:21

只看了第一个，是EE毕业的，能找到工作，和学搬砖的，自然不一样

作者: headhuanglan 时间: 2015-3-8 10:13:07

wang_come_on 发表于 2015-3-8 09:43
我个人的感觉是生物相关的方向工业界都不是很好找工作，因为这些产业都还不成熟。从学术的角度，生物材料也 ...

谢谢王版~！

作者: headhuanglan 时间: 2015-3-8 10:13:31

HumanEmpire 发表于 2015-3-8 10:04
只看了第一个，是EE毕业的，能找到工作，和学搬砖的，自然不一样

EE可以直接CS么...当然就业容易

作者: HumanEmpire 时间: 2015-3-8 10:15:49

headhuanglan 发表于 2015-3-8 10:13
EE可以直接CS么...当然就业容易

EE做生物材料就业也容易。。。
看的是skill set不是你的工作对象

作者: headhuanglan 时间: 2015-3-8 10:25:00

HumanEmpire 发表于 2015-3-8 10:15
EE做生物材料就业也容易。。。
看的是skill set不是你的工作对象

你说BME？方向很多 cs ee 很多方向的人都在做。。。我一搞computational material的...改投实验有点不合适。。。

作者: HumanEmpire 时间: 2015-3-8 10:29:03

headhuanglan 发表于 2015-3-8 10:25
你说BME？方向很多 cs ee 很多方向的人都在做。。。我一搞computational material的...改投实验有点不 ...

能computational就不要做实验。做实验说实话就是搬砖，对科研思维的训练，比computational的少，毕竟搬砖占了不少时间

作者: 672347250 时间: 2015-3-8 10:31:37

HumanEmpire 发表于 2015-3-8 10:15
EE做生物材料就业也容易。。。
看的是skill set不是你的工作对象

human叔觉得做企业项目（比如实习），但是干的活不是coding之类纯在电脑上进行的，也有实验，这样学到的skill set含金量就低些（对找工作来说）？

作者: 490560 时间: 2015-3-8 10:32:59

HumanEmpire 发表于 2015-3-8 10:29
能computational就不要做实验。做实验说实话就是搬砖，对科研思维的训练，比computational的少，毕竟搬砖 ...

computational里面是不是也有纯搬砖的？

作者: 672347250 时间: 2015-3-8 10:34:41

490560 发表于 2015-3-8 10:32
computational里面是不是也有纯搬砖的？

用成熟软件包，不怎么coding的应该算是搬砖吧

作者: headhuanglan 时间: 2015-3-8 10:34:59

490560 发表于 2015-3-8 10:32
computational里面是不是也有纯搬砖的？

搬砖的活你写code就自动完成了... 要想搬砖就是coding没学好

作者: 490560 时间: 2015-3-8 10:36:35

672347250 发表于 2015-3-8 10:34
用成熟软件包，不怎么coding的应该算是搬砖吧

对，我说的就是这种。

之前跟一个学长聊，他说他们组的代码都是CS technician写的，做科研时只要反复调参数实验就行了

作者: HumanEmpire 时间: 2015-3-8 10:39:44

490560 发表于 2015-3-8 10:32
computational里面是不是也有纯搬砖的？

少，毕竟code可以复制粘贴。
但是体力劳动不行

作者: HumanEmpire 时间: 2015-3-8 10:40:30

672347250 发表于 2015-3-8 10:34
用成熟软件包，不怎么coding的应该算是搬砖吧

可以用bash或者bat写，不用用鼠标点

作者: 672347250 时间: 2015-3-8 10:40:41

490560 发表于 2015-3-8 10:36
对，我说的就是这种。

之前跟一个学长聊，他说他们组的代码都是CS technician写的，做科研时只要反复调 ...

我觉得这里面有些矛盾，在工业上用的多，发展比较成熟的东西基本上都有成熟软件包，搞这种偏业界的方向貌似容易找工作但是缺乏human叔说的coding skill set的训练，但是做理论方向能训练出coding skill但是跟业界貌似有一定距离，所以我也比较困惑

作者: headhuanglan 时间: 2015-3-8 10:44:18

672347250 发表于 2015-3-8 10:40
我觉得这里面有些矛盾，在工业上用的多，发展比较成熟的东西基本上都有成熟软件包，搞这种偏业界的方向貌 ...

成熟软件包也可以进行2次开发以适应特定问题的~~ 要能独立2次开发你的python java C++一定学的棒棒哒！

作者: 672347250 时间: 2015-3-8 10:46:29

headhuanglan 发表于 2015-3-8 10:44
成熟软件包也可以进行2次开发以适应特定问题的~~ 要能独立2次开发你的python java C++一定学的棒棒哒！

java在学，感觉还是很有兴趣，但是算法感觉好难，不知道是不是要先把语言学精通再看算法就比较容易了啊？

作者: 490560 时间: 2015-3-8 11:10:43

HumanEmpire 发表于 2015-3-8 10:40
可以用bash或者bat写，不用用鼠标点

有很多不是鼠标点的问题，比如利用某个软件visualize之后与实验结果对比，其中就需要人的主观判断分析

作者: 490560 时间: 2015-3-8 11:11:48

672347250 发表于 2015-3-8 10:40
我觉得这里面有些矛盾，在工业上用的多，发展比较成熟的东西基本上都有成熟软件包，搞这种偏业界的方向貌 ...

工业上不一定都有成熟的软件包的，特别是如果你要做开发的话要write everything from scratch

作者: 490560 时间: 2015-3-8 11:13:20

672347250 发表于 2015-3-8 10:46
java在学，感觉还是很有兴趣，但是算法感觉好难，不知道是不是要先把语言学精通再看算法就比较容易了啊？

我感觉Java很繁琐，完全看不下去。。。。个人感觉C++/python相对好看一点

作者: 672347250 时间: 2015-3-8 11:27:27

490560 发表于 2015-3-8 11:11
工业上不一定都有成熟的软件包的，特别是如果你要做开发的话要write everything from scratch

能举个例子么？传统工业上用coding用的比较多的

作者: 672347250 时间: 2015-3-8 11:28:28

490560 发表于 2015-3-8 11:13
我感觉Java很繁琐，完全看不下去。。。。个人感觉C++/python相对好看一点

语言我都还是比较喜欢，就是看不进去算法。。。对抽象，逻辑的东西不感冒。。。

作者: 672347250 时间: 2015-3-8 11:30:54

490560 发表于 2015-3-8 11:10
有很多不是鼠标点的问题，比如利用某个软件visualize之后与实验结果对比，其中就需要人的主观判断分析

这就跟实验狗搬完砖分析实验结果是一样的啊

作者: 490560 时间: 2015-3-8 11:35:28

672347250 发表于 2015-3-8 11:27
能举个例子么？传统工业上用coding用的比较多的

传统工业指的是什么？data science, software development算不算？

作者: 672347250 时间: 2015-3-8 11:37:26

490560 发表于 2015-3-8 11:35
传统工业指的是什么？data science, software development算不算？

当然不算，指的是机械、化工、土木这种

作者: 490560 时间: 2015-3-8 11:38:24

672347250 发表于 2015-3-8 11:28
语言我都还是比较喜欢，就是看不进去算法。。。对抽象，逻辑的东西不感冒。。。

不看算法很多公司面试就直接刷掉了吧。。。

作者: 490560 时间: 2015-3-8 11:39:07

672347250 发表于 2015-3-8 11:37
当然不算，指的是机械、化工、土木这种

这就不知道了。。。这些工业好像对写code能力要求不高？

作者: 672347250 时间: 2015-3-8 11:42:03

490560 发表于 2015-3-8 11:39
这就不知道了。。。这些工业好像对写code能力要求不高？

我感觉也是。。。是不是对coding能力要求不高的skill set都没啥含金量？类似搬砖性质的？

作者: 672347250 时间: 2015-3-8 11:42:30

490560 发表于 2015-3-8 11:38
不看算法很多公司面试就直接刷掉了吧。。。

我是刚开始学，结果积极性被算法狠狠打击了。。。。

作者: 490560 时间: 2015-3-8 11:51:50

672347250 发表于 2015-3-8 11:42
我感觉也是。。。是不是对coding能力要求不高的skill set都没啥含金量？类似搬砖性质的？

不一定吧，coding只是众多skills中的一种，你如果有屌炸天的金融分析能力（不一定要很多coding的那一种）也非常有含金量

作者: 490560 时间: 2015-3-8 11:52:11

672347250 发表于 2015-3-8 11:42
我是刚开始学，结果积极性被算法狠狠打击了。。。。

是不是书太难了，你看的是什么书？

作者: 672347250 时间: 2015-3-8 11:55:03

490560 发表于 2015-3-8 11:52
是不是书太难了，你看的是什么书？

coursera上的算法part 1，普林斯顿的，完全是听天书。。。上了第一节union find就吃不消了。。。之前把head first java学了一遍，java基本概念都知道

作者: 490560 时间: 2015-3-8 11:56:37

672347250 发表于 2015-3-8 11:55
coursera上的算法part 1，普林斯顿的，完全是听天书。。。上了第一节union find就吃不消了。。。之前把he ...

这样。。。有参考教材么。。

作者: 672347250 时间: 2015-3-8 11:58:05

490560 发表于 2015-3-8 11:56
这样。。。有参考教材么。。

看了参考教材，感觉帮助不大，多看几遍勉强能理解，但是做练习完全不知道怎么独立思考

作者: 672347250 时间: 2015-3-8 11:58:56

490560 发表于 2015-3-8 11:56
这样。。。有参考教材么。。

可能是还不太习惯这种思维方式，多学几遍适应一段时间看能不能接受

作者: 490560 时间: 2015-3-8 11:59:44

672347250 发表于 2015-3-8 11:58
看了参考教材，感觉帮助不大，多看几遍勉强能理解，但是做练习完全不知道怎么独立思考

我看过一点这个：http://www.amazon.com/Data-Struc ... sis-C/dp/013284737X，感觉写得不错，Java版是这个：http://www.amazon.com/Data-Struc ... hm+analysis+in+java

你可以看看

作者: 672347250 时间: 2015-3-8 12:27:43

490560 发表于 2015-3-8 11:59
我看过一点这个：http://www.amazon.com/Data-Structures-Algorithm-Analysis-C/dp/013284737X，感觉写得 ...

谢谢！

作者: HumanEmpire 时间: 2015-3-8 13:42:33

490560 发表于 2015-3-8 11:51
不一定吧，coding只是众多skills中的一种，你如果有屌炸天的金融分析能力（不一定要很多coding的那一种） ...

你说的这些其他的能力，coding都是基础，如果没有coding的能力，其他都是空谈

作者: 490560 时间: 2015-3-8 20:40:51

HumanEmpire 发表于 2015-3-8 13:42
你说的这些其他的能力，coding都是基础，如果没有coding的能力，其他都是空谈

嗯，不过金融分析行业好像对纯coding要求不是很高，代码一般不到1000行

作者: 672347250 时间: 2015-3-9 09:16:01

490560 发表于 2015-3-8 20:40
嗯，不过金融分析行业好像对纯coding要求不是很高，代码一般不到1000行

懂了，不coding的都是搬砖，没前途，滚去看算法去了。。。

欢迎光临寄托家园留学论坛 (https://bbs.gter.net/)