Opening for PhD students at City University of Hong Kong
We are now having opening for PhD students from a variety of backgrounds (mechanical engineering, chemical engineering, biomedical engineering, chemistry, biology). Candidates with cell culture, nanotechnology, or microfabrication will be highly preferred.
Located in the heart of Hong Kong, City University of Hong Kong (CityU) has a well-earned reputation as an innovative hub for research and professional education and for addressing global issues and empowering positive change. In 2021, CityU is ranked 54th in [QS] World University Rankings 2023 and 4th in [QS] "Top 50 under 50" in 2021.
Our lab is focusing on leveraging micro/nanotechnology for investigation of mechanobiology. We have particular interest in cell’s left-right bias, e.g. rightward biased migration, rotation, and orientation. We recently discovered that cells can generate a torque with rotational bias depending on cell types. As a leading group in such rotational mechanics, our research provides a fundamental framework in guiding cell mechanics, stem cell differentiation, and tissue regeneration. Some related publications can be found below:
Yuanye Bao, Siying Wu, Lok Ting Chu, Hoi Kwan Kwong, Hogi Hartanto, Yaozhun Huang, Miu Ling Lam, Raymond H. W. Lam & Ting-Hsuan Chen*, Early Committed Clockwise Cell Chirality Up-Regulates Adipogenic Differentiation of Mesenchymal Stem Cells. Advanced Biosystems, vol. 4, pp. 2000161 , 2020
Hoi Kwan Kwong, Yaozhun Huang, Yuanye Bao, Miu Ling Lam, Ting-Hsuan Chen*, Remnant Effects of Culture Density on Cell Chirality After Reseeding, ACS Biomaterials Science & Engineering, vol. 5/8, pp. 3944-3953, 2019
Wei Liu, Yuanye Bao, Miu Ling Lam, Ting Xu, Kai Xie, Hin Sum Man, Edward Y. Chan, Ninghao Zhu, Raymond H. W. Lam, and Ting-Hsuan Chen*, Nanowire Magnetoscope Reveals a Cellular Torque with Left-Right Bias, ACS Nano, vol. 10(8), pp. 7409 - 7417, 2016
In addition, We are also interested in development of biosensors based on nanotechnology and DNA nanomachines. That is to detect biomarkers in live cells or microfluidics assays for portable biosensors. Some related publications can be found below:
Minghui Wu, Siying Wu, Gaobo Wang, Wengang Liu, Lok Ting Chu, Tianyi Jiang, Hoi Kwan Kwong, Hiu Lam Chow, Iris Wai Sum Li, Ting-Hsuan Chen*, Microfluidic Particle Dam for Direct Visualization of SARS-CoV-2 Antibody Levels in COVID-19 Vaccinees, Science Advances, vol. 8, eabn6064, 2022
Gaobo Wang, Jiaheng Li, Siying Wu, Tianyi Jiang, and Ting-Hsuan Chen*, A Fully Integrated, Ready-to-Use Distance-Based Chemosensor for Visual Quantification of Multiple Heavy Metal Ions, Analytical Chemistry, in press, https://doi.org/10.1021/acs.analchem.2c04712
Chenyu Cui, Cia-Hin Lau, Chung Tin, Ting-Hsuan Chen*, Multimodal Detection of Flap Endonuclease 1 Activity through CRISPR/Cas12a Trans-cleavage of Single-strand DNA Oligonucleotides, Biosensors and Bioelectronics, vol. 220, pp. 114859, 2023
Lok Ting Chu, Hoi Kwan Kwong, Hogi Hartanto, Ting-Hsuan Chen*, Detection of intracellular sodium ions based on phenotype-specific activation of NaA43 DNAzyme, Biosensors and Bioelectronics, vol. 218, pp. 114753, 2022
Monthly studentship: HKD 18,527
Regular study period in City U: 4 years
We are open to inquiries regarding the interests of joining our group. If interested, please send you CV and also include the transcripts and English test result (TOEFL, IELTS, or CET-6). The inquiry should be addressed to: thchen@cityu.edu.hk.