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【博士招生】英国伦敦玛丽女王大学(Queen Mary)招2023 CSC 博士(生物类,表观遗传学) [复制链接]

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发表于 2023-1-20 19:01:48 |显示全部楼层
【博士招生】英国伦敦玛丽女王大学(Queen Mary University of London)招2023入学 CSC资助 博士生(生物大类,表观遗传学方向)
帮老板招生。
Dr Alexandre de Mendoza Soler 团队招收一名由CSC(国家留学基金委)资助的博士生,由Dr Paul Hurd共同指导,Queen Mary University of London的申请截至2023年1月31日。成功后于3月申请CSC。详细要求及项目方向见下方链接。导师邮箱:a.demendozasoler@qmul.ac.uk
https://www.qmul.ac.uk/sbbs/postgraduate/phd-programmes/projects/display-title-1001384-en.html

【关键信息】

1. Queen Mary申请1月31号截至,CSC申请3月截至。

2.实验室主页:
https://www.demendozalab.com/

3.项目方向:
Cytosine DNA methylation is one of the most studied epigenetic marks in eukaryotes, with established roles in genome regulation and selfish DNA silencing. Still, we do not fully understand how methylation influences transcription. In part, that limitation is linked to the widespread focus on few highly complex model systems, mostly mammals or plants, with highly complex methylation patterns. In this project we want to fill this gap by understanding the evolution of cytosine methylation “readers”, proteins capable of exclusively binding to methylated cytosines. To this end, we will use comparative genomics and proteomics on multiple eukaryotes with simpler methylation landscapes, occupying key positions in the tree of life. The proteins identified in the previous approach will be then validated using functional genomics (e.g. DAP-seq, ChIP-seq).
This project will reveal how the various gene families that are known to have roles in DNA methylation interpretation evolved, and potentially will discover new proteins with this capacity. Ultimately, understanding how eukaryotic genomes interpret DNA methylation is important to clarify the roles of this epigenetic mark in genome regulation. In turn, these findings will have applications in synthetic biology approaches. Given the key roles DNA methylation has in human disease, including cancer, an evolutionary-informed mechanistic understanding of this epigenetic mark is critical, as the various genes and mechanisms we learn in divergent eukaryotes can be then used to read and interpret our own epigenome.


4.大致要求:
Applications are invited from outstanding candidates with or expecting to receive a first or upper-second class honours degree and a masters degree in an area relevant to the project (Molecular Biology, Bioinformatics, Biochemistry). A masters degree is desirable, but not essential.
For this PhD, any previous experience on molecular biology work, from cloning to protein purification would be highly benefitial. Furthermore, some basic knowledge of bioinformatics would also be helpful, although we are happy to provide training on this aspect. The project would combine wet lab and bioinformatics.

5. 语言要求:
IELTS Academic: 6.5 overall including 6.0 in Writing and 5.5 in Reading, Listening and Speaking.
TOEFL: 92 overall including 21 in Writing, 18 in Reading, 17 in Listening and 20 in Speaking.
PTE Academic/PTE Academic UKVI: 62 overall including 57 in Writing and 51 in Reading, Listening and Speaking.

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