1. 研究目标:promotes developing an integrated view of the organism vis-á-vis large-scale genomics and comparative genomics research
2. 研究方向: Computational Approaches to Functional and Integrative Genomics ;Theoretical Molecular Biology and Computational Algorithms ;Computational Analysis of Macromolecular Structures ;Heterogeneous Database Design and Information Integration
3. 录取要求: 1) a strong foundation in the basic sciences, such as biology, chemistry and mathematics; and 2) training in computing/informatics, including significant computer programming experience. The Graduate Record Examination (GRE) General Test is required, and the GRE Subject Test in cell & molecular biology, biology, biochemistry, chemistry, computer science, or other relevant discipline is recommended. Applicants for whom English is not their native language are required to submit results from the Test of English as a Foreign Language (TOEFL).
4. 学习计划和培养目标: http://ycmi.med.yale.edu/CBB/CBBProg.html 。
5. 师资力量:目前共有30位教授, http://info.med.yale.edu/bbs/biocom/faculty.html 。Yale的Center for Genomics and Proteomics也列出了Bioinformatics方面的教授:http://cgp.yale.edu/bioinformatics/index.html 。
推荐的教授有:
(1) Mark Gerstein, 实验室的网址是 http://bioinfo.mbb.yale.edu/ 。他目前是这个track的graduate studies的director,研究方向包括:(i) analysis of structures, focused on understanding protein motions in terms of packing; (ii) analysis of sequences, focused on surveying the occurrence of folds and families in genomes (both for genes and pseudogenes); (iii) analysis of functional genomics data, focused on trying to predict protein function on a genomic scale.
(2) Hongyu Zhao, 实验室的网址是 http://zhao.med.yale.edu/ 。研究方向包括:(i) Genetic Linkage and Association Studies and Population Genetics;(ii) Computational Biology (an integrated understanding of the genetic networks underlying complex biological phenotypes. We are focusing on developing statistical and computational methods to integrate different types of genomics and proteomics data to dissect biological pathways, including metabolic pathways, transcriptional regulatory pathways, and signal transduction pathways); (iii)Proteomics
德州的贝勒医学院Balyor College of Medicine排名第13。Baylor College of Medicine, Rice University, The University of Houston, The University of Texas M.D. Anderson Cancer Center, and The University of Texas - Houston Health Science Center合办了Ph.D. Program in
Structural and Computational Biology and Molecular Biophysics, http://scbmb.bcm.tmc.edu/ 。
推荐的教授有:
(1) Aleksandar Milosavljevic, 实验室网址是 http://brl.bcm.tmc.edu/ 。研究方向包括:developing new methods and creates new resources for discovery through comparative genomics and informatics。
(2) Richard Gibbs,实验室的网址是 http://www.hgsc.bcm.tmc.edu/ 。他目前是Baylor College of Medicine - Human Genome Sequencing Center 的director。研究方向包括:The Human Genome Project; molecular basis of human genetic diseases; molecular evolution。
(3) Jonathan Miller,http://scbmb.bcm.tmc.edu/people/gcc_faculty_179 。研究方向包括: Theoretical/computational studies of microRNAs and anti-sense RNAs; gene regulation; networks; biological membrane structure and dynamics 。
4. 学习课程安排请参看: http://scbmb.bcm.tmc.edu/program/curriculum 。
同在德州的西南医学院 University of TX Southwestern Medical Center于2004年在Molecular Biophysics Profeam设立了一个Computational Biology Track, http://biophysics.swmed.edu/page_3/ 。
1. 培养目标: for students who are interested in using mathematical and computational modeling techniques to understand biological and biochemical processes
2. 录取要求: 申请者首先要被Graduate Program in Molecular Biophysics录取。 申请者应该有undergraduate training, or demonstrated competence in the use of computer operating systems, and working knowledge of one or more high-level computer programming languages (C/C++, Java, FORTRAN, Perl, Ada, Pascal, etc). Students should also have a solid background in mathematics through calculus and basic statistics as demonstrated by their undergraduate transcripts.
3.研究方向: Computational Genomics
o DNA/Protein Sequence Analysis
o Sequence Analysis and Annotation
o Alignment Methods
o Comparative Genomics
o Computational Analysis of Proteins
o Structure Prediction Methods
o Comparative Modeling
o Molecular Dynamics
Data Mining And Databases
o Comparison Methods (Sequences, Structures, Abstracts)
o Database Searching
o Biological Data Structures
Structure Determination Methods
Biological Systems Modeling
Comparative Modeling
4. 师资力量: http://biophysics.swmed.edu/page_3/
Dr. Harold Garner
Dr. Nick Grishin
Dr. Zbyszek Otwinowski
Dr. Alexander Pertsemlidis
Dr. Rama Rangananathan
Dr. Elliot Ross
Dr. Richard Scheuermann
Electives (3 credits)
Any of the 1.5 credit courses offered by the Molecular Biophysics Program (below) or any of the approved 3 credit electives in Computer Science or Mathematical Sciences offered at U.T.Dallas (See Appendix).
MB 5145-01 Computational Approaches in Protein Science 1.5 credits
MB 5125-01 Computational Modeling of Signaling Systems 1.5 credits
MB 5096-01 Bioinformatics and DNA Microarray Data Analysis 1.5 credits