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非常想死~~~~~现在~~~
痛苦极了~~~
先睡觉~
daily burn... endless burn......:(:(:(
:confused::confused:
The following concepts underlie the remainder of the chapter:
1. Disease presentation is often atypical in the elderly, especially in those >75 to 80 years old. Homeostatic strain caused by onset of a new disease often leads to symptoms associated with a different organ system, particularly one compromised by preexisting disease. For example, fewer than one-fourth of older patients with hyperthyroidism present with goiter, tremor, and exophthalmos; more likely are atrial fibrillation, confusion, depression, syncope, and weakness. Significantly, because the “weakest link” is so often the brain, the lower urinary tract, or the cardiovascular or musculoskeletal system, a limited number of presenting symptoms predominate—acute confusion, depression, incontinence, falling, and syncope—no matter what the underlying disease. Thus for the most common geriatric syndromes, regardless of the presenting symptom, the differential diagnosis is often largely similar. The corollary is equally important: The organ system usually associated with a particular symptom is less likely to be the source of that symptom in older individuals than in younger ones. Compared with middle-aged individuals, for example, acute confusion in older patients is less often due to a new brain lesion, depression to a psychiatric disorder, incontinence to bladder dysfunction, falling to a neuropathy, or syncope to heart disease.
2. Because of decreased physiologic reserve, older patients often develop symptoms at an earlier stage of their disease (Fig. 8-1). For example, heart failure may be precipitated by mild hyperthyroidism, cognitive dysfunction by mild hyperparathyroidism, urinary retention by mild prostatic enlargement, and nonketotic hyperosmolar coma by mild glucose intolerance. Paradoxically, therefore, treatment of the underlying disease may be easier because it is frequently less advanced at the time of presentation. A corollary is that drug side effects can occur with drugs and drug doses unlikely to produce side effects in younger people. For instance, a sedating antihistamine (e.g., diphenhydramine) may cause confusion, loop diuretics may precipitate urinary incontinence, digoxin may induce depression even with normal serum levels, and over-the-counter sympathomimetics may precipitate urinary retention in men with mild prostatic obstruction.
Unfortunately, the predisposition to develop symptoms at an earlier stage of disease is often offset by two factors. First, symptoms may present later if there is functional limitation in another system. Coronary artery disease or aortic stenosis may not cause symptoms as early in patients whose mobility is compromised by arthritis. Second, a change in illness behavior occurs with age. Raised at a time when symptoms and debility were accepted as normal consequences of aging, the elderly are less likely to seek attention until symptoms become disabling. Thus, any symptom, particularly those associated with a change in functional status, must be taken seriously and evaluated promptly.
3. Since many homeostatic mechanisms may be compromised concurrently, there are usually multiple abnormalities amenable to treatment, and small improvements in each may yield dramatic benefits overall. For instance, cognitive impairment in patients with Alzheimer's disease may respond much better to interventions that alleviate comorbidity than to prescription of a cholinesterase inhibitor (Fig. 8-2). Similar approaches apply to most other geriatric syndromes, including falls, incontinence, depression, delirium, syncope, and fracture. In each case, substantial functional improvement can result from treating the contributing factors even if—as in Alzheimer's disease—the disease itself is largely untreatable.
4. Many findings that are abnormal in younger patients are relatively common in older people—e.g., bacteriuria, premature ventricular contractions, low bone mineral density, impaired glucose tolerance, and uninhibited bladder contractions. However, they may not be responsible for a particular symptom but only be incidental findings that result in missed diagnoses and misdirected therapy. For instance, the finding of bacteriuria should not end the search for a source of fever in an acutely ill older patient, nor should an elevated random blood sugar—especially in an acutely ill patient—be incriminated as the cause of neuropathy. On the other hand, certain other abnormalities must not be dismissed as due to old age—e.g., there is no anemia, impotence, depression, or confusion of old age.
5. Because symptoms in older people are often due to multiple causes, the diagnostic “law of parsimony” often does not apply. For instance, fever, anemia, retinal embolus, and a heart murmur prompt almost a reflex diagnosis of infective endocarditis in a younger patient but may reflect aspirin-induced blood loss, a cholesterol embolus, insignificant aortic sclerosis, and a viral illness in an older patient. Moreover, even when the diagnosis is correct, treatment of a single disease in an older patient is unlikely to result in cure. For instance, in a younger patient, incontinence due to involuntary bladder contractions is treated effectively with a bladder relaxant medication. However, in an older patient with the same condition but who also has fecal impaction, takes medications that cloud the sensorium, and suffers from arthritis-associated impairments of mobility and manual dexterity, treatment of the bladder spasms alone is unlikely to restore continence. On the other hand, disimpaction, discontinuation of the offending medications, and treatment of the arthritis are likely to restore continence without the need for a bladder relaxant. Failure to recognize these principles often leads to prescribing “ineffective” therapy and to unjustified therapeutic nihilism toward older patients.
6. Because the older patient is more likely to suffer the adverse consequences of disease, treatment—and even prevention—may be equally or even more effective. For instance, the survival benefits of exercise, as well as thrombolysis and beta-blocker therapy after a myocardial infarction, are as impressive in older patients as in younger ones; and treatment of hypertension and transient ischemic attacks, as well as immunization against influenza and pneumococcal pneumonia, are more effective in older patients. A proactive approach is even more effective in acute care, in which it decreases the risk of delirium by 30 to 60%. In the outpatient setting, such an approach can delay functional decline and institutionalization. In addition, prevention in older patients must often be seen in a broader context. For instance, although interventions to increase bone density may be limited in older patients, fracture may still be prevented by efforts to improve balance, strengthen legs, reduce peripheral edema, treat other contributing medical conditions, replete nutritional deficits, eliminate environmental hazards, and remove adverse medications—not so much those that affect bone metabolism, but rather those that induce orthostasis, confusion, and extrapyramidal stiffness.
In summary, optimal treatment of the older patient generally requires treating much more than the organ system usually associated with the disease or symptom, and often permits ignoring that system entirely.
谢谢我的朋友,每次到了过节的时候,就是我心情最不好的时候
昨天难过得拼命吃(饼干一袋,花生,面条,馒头,花生),然后吐了2次,拼命的喝水(昨天喝光了2个保温壶的开水6+6磅)。
今天也是,吐了2次,喝水喝到低血钾~~~~~
一天没有吃东西,刚刚又开始狂吃~~~~~
今天不睡了,自虐到累得没有力气难过为止。
[ Last edited by zhangheng1020 on 2005-12-24 at 20:42 ] |
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