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[未归类] 谁再帮我找两篇文献 <done> [复制链接]

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Pisces双鱼座 荣誉版主 寄托之心勋章

发表于 2009-11-19 17:12:44 |显示全部楼层
1. Animal models of depression in drug discovery: a historical perspective.

作 者: McArthur RBorsini F 刊 名: Pharmacology, Biochemistry and Behavior  年,卷(期): 2006vol.84(no.3)  

2. Animal modeling of depressive disorders
European Neuropsychopharmacology, V
olume 15, Issue null, Pages S89-S91
B.Leonard

另外12月2,3日在天津,然后在北京度周末,谁能出来聚聚?tree?小楚?
公谨二十四经略中原,妻小乔,羽扇纶巾, 谈笑间破孟德八十三万于赤壁。今吾亦当此岁,但少睡多忧,贤愚竟相远如此.

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囧章 Gemini双子座 枫情万种 一帆枫顺   枫华绝代 荣誉版主

发表于 2009-11-19 17:41:05 |显示全部楼层
No.1

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囧章 Gemini双子座 枫情万种 一帆枫顺   枫华绝代 荣誉版主

发表于 2009-11-19 17:42:31 |显示全部楼层
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Aquarius水瓶座 荣誉版主 挑战ETS奖章 US Advisor Golden Apple

发表于 2009-11-19 17:43:39 |显示全部楼层
我找了全文但是下载要30多刀.....


Abstract
Over the course of the last 50 years many models of major depressive disorder have been developed on the basis of theoretical aspects of this disorder. These models and procedures have been crucial in the discovery and development of clinically-effective drugs. Notwithstanding, there is presently great concern about the discrepancy between positive outcomes of new candidate drugs in animal models and apparent lack of efficacy in humans i.e., the predictive validity of animal models. Some reasons for this concern lie in the over-reliance in the face value of behavioural models, design of clinical trials, placebo responses, genetic variations in response to drugs, species differences in bioavailability and toxicology, and not least, disinterest of pharmaceutical sponsors to continue developing certain drugs. Present model development is focusing on endophenotypic aspects of behaviours rather than trying to model whole syndromes. This essay traces the origins and theoretical bases of our animal models of depression or depressed-like behaviours in humans and indicates how they have evolved from behavioural assays used to measure the potency and efficacy of potential candidate drugs to tools by which endophenotypes of depression may be identified and verified pharmacologically. A cautionary note is included though to indicate that the true predictive validity of our models will not be fully assessed until we can determine the attrition rate of molecules discovered from new drug targets translating into clinically-effective drugs.

Keywords: Animal; Models; Depression; Review; Stress; Anhedonia; Clinical trial; Placebo; Pharmacogenomics; Endophenotypes; Validity; Translational research

Article Outline
1. Introduction
2. Origins of animal models of major depressive disorder
3. Neurochemical models of depression
4. Ethological models of depression based on social stress (separation, prolonged isolation, social hierarchy)
5. Ethological models of depression, based on environmental stress (learned helplessness, forced swimming test/tail suspension, chronic stress)
6. Olfactory bulbectomy
7. Operant response models
8. Natural genetic models of depression
9. Other tests and models proposed
9.1. Electrical kindling
9.2. Chemical convulsants
9.3. Circadian rhythms and phase-shift
10. Present directions: genetic approaches to modelling depressed-like behavioural endophenotypes
10.1. Genetic techniques and behavioural analyses
10.2. Modelling endophenotypes: anhedonia
11. So why aren't we producing new antidepressants?
12. Are we measuring the same thing in animal models of depression that is being measured in groups of depressed patients in clinical trials?
13. Where do we go from here?
14. Conclusions
References

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Aquarius水瓶座 荣誉版主 挑战ETS奖章 US Advisor Golden Apple

发表于 2009-11-19 17:51:44 |显示全部楼层
第2个

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Aquarius水瓶座 荣誉版主 挑战ETS奖章 US Advisor Golden Apple

发表于 2009-11-19 17:52:36 |显示全部楼层
猜猜动作真快!

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囧章 Gemini双子座 枫情万种 一帆枫顺   枫华绝代 荣誉版主

发表于 2009-11-19 18:12:46 |显示全部楼层
猜猜动作真快!
yanhuangbaby 发表于 2009-11-19 17:52


我最近几个project都赶到一起 读了有将百篇文章 下论文的动作都麻木了
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寄托兑换店纪念章 梦舞槿樱 2015 US-applicant 寄托之心勋章 Libra天秤座 在任资深版主 Sub luck 读书种子 寄托16周年纪念勋章

发表于 2009-11-20 02:16:33 |显示全部楼层
TREES估计没戏吧。哈
真幸福。我也想回去
以上言论仅代表个人观点

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Pisces双鱼座 荣誉版主 寄托之心勋章

发表于 2009-11-20 12:39:10 |显示全部楼层
谢谢
公谨二十四经略中原,妻小乔,羽扇纶巾, 谈笑间破孟德八十三万于赤壁。今吾亦当此岁,但少睡多忧,贤愚竟相远如此.

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发表于 2009-11-20 13:01:23 |显示全部楼层
bukeqi .haha
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谁再帮我找两篇文献 <done>
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