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18.A game of consequences?
One of the scourges of modern life may have been profoundly misunderstood
Mar 11th 2010 | From The Economist print edition
BEING fat is bad for you. On that, almost everyone agrees. It is just possible, though, that almost everyone is wrong. In fact, getting fat may be a mechanism that protects the body. The health problems associated with fatness may not be caused by it but be another consequence, another symptom, of overeating.( 实际上,发胖可能是保护身体的方法。与肥胖有关的健康问题或许并不是肥胖本身引起的,而是暴饮暴食的又一个后果,又一个症状。)
symptom
[ˈsimptəm] n.症状;征候,征兆
That is the heretical proposal of Roger Unger and Philipp Scherer. (这正是罗杰•昂格尔和菲利普•谢勒提出的颠覆传统的观点。)Dr Unger and Dr Scherer, who work at the University of Texas, in Dallas, have been reviewing the science of what has come to be known as metabolic syndrome. This is a cluster of symptoms such as high blood pressure, insulin resistance and fatness that seem to increase the risk of heart disease and strokes, late-onset diabetes and liver disease. Metabolic syndrome is found in a sixth of the American population.
heretical adj 异端邪说的;异教的
“Syndrome” is the medical term for a collection of symptoms whose common cause is not properly understood. The symptom of metabolic syndrome that appears first is usually obesity, so this is generally regarded as the underlying cause.
obesity n.肥胖
underlying adj 在下面的;根本的;基础的;
含蓄的,潜在的
Dr Unger and Dr Scherer, however, turn this logic on its head. They point out that there is usually a period of many years between a person becoming overweight and his developing the other symptoms. If the growth of adipose tissue (the body cells in which fat is stored) were directly harmful, that would not be the case. This is one of the lines of evidence that has led them to the conclusion that, in addition to its role in storing energy as a hedge against future famine, getting fat is a protective mechanism against metabolic syndrome.
adipose ['ædipəus;'ædəˌpəus] adj. 脂肪的n. 脂肪
hedge n 树篱(一排密种的灌木或低树形成的栅栏或分界线);(由一排人或物体组成的)障碍; 预防措施
Their thesis is that lipids (the group of molecules that includes fats), which are needed in small amounts to make cell membranes, are toxic in larger quantities. Absorbing them into adipose tissue is one of the body’s ways of dealing with that toxicity. But are lipids toxic? In one sense, it is obvious that they are. The build up of fatty plaques in blood vessels, which results in atherosclerosis, is a result of the inability of the cells lining the walls of these vessels to cope with too much fat.
thesis ['θi:sis] n. 毕业论文,论题,论文
lipids [;'lipidz] n. 脂质,类脂
membrane n 薄膜(薄而柔软的组织层,覆盖在表面)细胞膜
plaque n 血小板;斑(动脉血管壁内脂肪物质的沉积)
atherosclerosis [ˌæθərəuskli'rəusis] [医]动脉硬化
Fat, and proud of it
More subtly, though, the two researchers have dug up evidence that an excess of lipids damages heart-muscle cells, and even destroys pancreatic cells in rodents. This could help explain the fact that the form of diabetes that follows metabolic syndrome can involve damage to pancreatic cells.
subtly ['sʌtli;'sʌtəli] adv. 敏锐地,巧妙地,精细地
dug up v. 掘起(挖松,发现)
pancreatic [ˌpæŋkri'ætik] adj. 胰脏的
It is generally thought that the growth of adipose tissue causes cells in the liver, muscle and fat tissue to become resistant to insulin (a hormone produced in the pancreas) and thus unable to absorb glucose from the blood. How this happens has been the subject of a lot of hand waving, though the tendency of adipose tissue to produce chemicals that encourage inflammation is often mentioned.( 这一现象的发生一直是一个扑朔迷离的话题,但是脂肪组织倾向于产生恶化炎症的化学物质这一点却经常被提及。)
pancreas n.胰脏
inflammation n 点火;发炎(表现为疼痛、红肿,有时丧失功能);激怒
【反】mollification(n 缓和)"
Dr Unger and Dr Scherer attack this whole notion. In a paper in Trends in Endocrinology and Metabolism they argue that insulin resistance is another side-effect of metabolic syndrome whose cause is lipid molecules poisoning tissues in which they are not supposed to be present in large quantities. The problem of lipid damage, they believe, is linked to hormones produced not by the pancreas, but by adipose tissue itself. These hormones are called leptin and adiponectin.
leptin n. 瘦素
Adiponectin n. [医]脂联素
Leptin has several roles, but one is to encourage cells to oxidise lipids and thus destroy them. For example, in the cases of the heart-muscle cells and pancreatic cells mentioned above, dosing them with leptin keeps them healthy. Adiponectin, meanwhile, encourages the body’s adipose tissue to absorb lipids.
oxidize v 使氧化,使生锈
As adipose tissue grows, however, its production of adiponectin falls. The ability of the tissue to absorb lipids and keep the rest of the body safe thus drops. Leptin production, meanwhile, grows along with the mass of the adipose tissue. In what is, admittedly, the least-tested part of their thesis, Dr Unger and Dr Scherer argue that other cells react to this increase in leptin concentration by becoming resistant to the hormone’s effects. That, in turn, stops them oxidising lipids and opens those cells to lipids’ toxic effects.( 昂格尔和谢勒博士的理论中有一部分证据最为不充分,在这一部分中,他们称其他细胞会对瘦素的累积产生反应,开始对激素的作用产生抵抗,从而不再对脂质进行氧化,是它们受到脂质毒性的攻击。)
Dr Unger and Dr Scherer suggest that this failure of the leptin mechanism, particularly its role in oxidising lipids, is crucial to the development of metabolic syndrome, and that it is a pathology of adipose tissue that has become overloaded.
In light of all this, they suggest that insulin resistance, like obesity, should be viewed not as a pathology but as an adaptive response by the body to an excess of circulating lipids. To save themselves when they are threatened with being overwhelmed by lipids, cells become insulin-resistant, which stops them taking up extra glucose which would then be converted into lipids.
circulate
[ˈsə:kjuleit]v.(使)循环;(使)流传,传播
In support of this hypothesis, the researchers point to studies on mice whose leptin receptors have been broken by genetic mutations. In a healthy mouse (one with working leptin receptors) even a diet that is 60% fat does not cause a build-up of lipids anywhere except in the adipose tissue. In one with broken receptors, a mere 6% is enough to overload other tissues to the point where lipids would be toxic. Such experiments cannot, of course, be done on people, but something similar occurs naturally. A few unfortunates are born without adipose tissue. These people rapidly develop the symptoms of metabolic syndrome.
mutation n 突变(生物的基因或染色体产生父代没有的新的特征)
Sadly for self-indulgent humans, none of this affects the basic message about staying healthy, which remains to eat less and exercise more. It does, though, raise important questions about how metabolic syndrome is treated. The focus that many doctors have on controlling diabetes may be mistaken, possibly counterproductive, if insulin resistance is actually a protective mechanism. Even if it is not, the destruction of pancreatic cells that comes with diabetes may be unrelated to the development of insulin resistance. And liposuction (not, admittedly, something that most doctors would recommend) would be expected to make things worse, since it would get rid of the source of the hormones that regulate lipids.
indulgent adj 放纵的;采取宽容放纵行为的=lenient
liposuction ['lipəuˌsʌkʃən]n. 吸脂术
Dr Unger and Dr Scherer, then, have attempted to apply some new thinking to a disease that affects more people as the world gets richer. Even if they are wrong, a little lateral thinking may help shake up the field(一点横向思维也能够给这一领域带来翻天覆地的变化). If they are right, a lot of people may thank them in the future. |