University of Nebraska, Nutrition and Health Sciences实验室招收博士研究生

qsu2UID: 3396566

PI： Dr. Qiaozhu Su, University of Nebraska-Lincoln, Department of Nutrition and Health Sciences
研究领域: 最新前沿热点 “Cellular stress signaling and metabolic syndrome”。更多信息请进入PubMed   
                    进行搜索。
研究对象: 动物和细胞模型(genetic engineering or dietary induced metabolic disease animal models，
                    primary cells and cell lines).
基本要求：GRE成绩 TOFEL成绩。
选择性要求：课题需要进行动物实验，尤其是动脉插管，肝脏灌流和原代细胞分离。申请者要求有糖脂代
                            谢研究背景，动物实验经验并掌握基本的分子生物学技术。有硕士背景和/或专业文献发表者
                            将给予优先考虑。
生活资助:学生将得到RA(Research Assistantship)作为生活资助。
联系方式：qsu2@unl.edu

**本实验室也欢迎也有相关背景的国家公派访问/交流学者到实验室来开展课题。具体另外祥谈。

以下为Dr. Su的实验室介绍：

An important goal of Su’s laboratory is to investigate the associations between cellular stress signaling, lipid/lipoprotein metabolism as well as the underlying molecular mechanisms responsible for metabolic syndrome, such as obesity, cardiovascular disease and diabetes. Her program concerns three main areas: (1) To investigate the role of eIF2 alpha kinases, the dsRNA activated protein kinase (PKR) and the heme regulated inhibitor (HRI), in atherogenic diets induced obesity and insulin resistance. This project will study the cross-talk between mitochondrial stress and ER stress induced by high fat diets and their contributions to the onset of metabolic syndrome. (2) To elucidate the mechanisms responsible for hyperactivation of hepatic de novo lipogenesis in insulin resistant animal models by investigating the interplay between two transcription factors, SREBP and CREBH, and their association with adaptor proteins, Insig-1, Insig-2 and SCAP. (3) To determine the mechanisms responsible for overproduction of very low density lipoprotein (VLDL) in subjects with obesity and diabetes. This concern will be addressed by delineating the assembly and secretion of VLDL from liver and its lipolysis in the circulation system. Specific attention will be paid to the peroxisome proliferator-activated receptor family (PPAR alpha family, microsomal triglyceride transfer protein (MTP)) and kinases involved in mediating cellular stress signaling, including PKR and PERK, in cell culture systems (e.g. hepatocytes, fibroblasts and adipocytes) as well as in insulin-resistant animal models induced by genetic intervention and/or lipogenic diets. Dr. Su hopes that her research program will lead to the identification of nutrient supplement(s) and/or pharmaceutical target(s) for the prevention and treatment of metabolic diseases.

Students in Su’s laboratory will receive a broad and comprehensive training to discover novel links between nutrient surplus, lipid/lipoprotein metabolism and cellular stress signaling in the onset of chronic metabolic diseases. Each trainee will have an independent project and also be involved in topic-common projects in the laboratory to broaden their knowledge of biomedical sciences.

感谢各位的关注！

H1BMatch2012UID: 2790388

ER stress啊，实际一直想问，ER stress应该induce UPS activity change吧，结果参加的会议谈到ER stress的大将做的时候貌似没人对这个感兴趣，那么多教授都不谈啊。

纯吐槽，UNL很好啊，典型的中西部大农村被低估的例子，虽然俺更喜欢UNMC一些。