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本帖最后由 MIUseliza 于 2015-8-5 14:50 编辑
Few areas of neurobehavioral research seemed more promising in the early sixties than that investigating the relationship between protein synthesis and learning.which had shown that genetic information is stored in nucleic acids and expressed in proteins. Why not acquired information as well?
没什么research比NB research investigating the relationship between protein synthesis and learning更有前景。这种research的框架概念全部来自 MB (showed that genetic info is stored in nucleic acids and expressed in proteins). 为什么后天获得的信息不可以这样?
The first step toward establishing a connection between protein synthesis and learning seemed to be to block memory (cause amnesia) by interrupting the production of proteins. We were fortunate in finding a nonlethal dosage of puromycin that could, it first appeared, thoroughly inhibit brain protein synthesis as well as reliably produce amnesia.
干扰蛋白质产生来封锁记忆。由于找PS和L的联系需要先屏蔽记忆,也就是让人失忆,我们很幸运能找到一个可以一直蛋白质合成作用然后造成失眠
Before the actual connection between protein synthesis and learning could be established, however, we began to have doubts about whether inhibition of protein synthesis was in fact the method by which puromycin produced amnesia. First other drugs, glutarimides—themselves potent protein-synthesis inhibitors—either failed to cause amnesia in some situations where it could easily be induced by puromycin or produced an amnesia with a different time course from that of puromycin. Second puromycin was found to inhibit protein synthesis by breaking certain amino-acid chains, and the resulting fragments were suspected of being the actual cause of amnesia in some cases. Third, puromycin was reported to cause abnormalities in the brain including seizures. Thus, not only were decreased protein synthesis and amnesia dissociated, but alternative mechanisms for the amnestic action of puromycin were readily suggested
在PS与学习之间的联系能够实现以前,我们就开始怀疑抑制PS的合成是否这的是P通过让人失忆的方法产生。首先,其他药物,G,本身是蛋白质合成的抑制剂,既不能引起P在某些情况下P能引起的失忆,也不能产生和P不一样的时间进程。第二,发现P是打断某种氨基酸脸的办法来抑制PS, 残余物可能是真正引起失眠的原因。第三P回造成大脑不正常,包括并发症状。因此,不光减少的PS和失忆没有了联系,而且关于P的另外供选择的方法很快就提出来。
So, puromycin turned out of be a disappointment. It came to be regarded as a poor agent for amnesia studies, although, of course, it was poor only in the context of our original paradigm of protein-synthesis inhibition. In our frustration, our initial response was simply to change drugs rather than cur conceptual orientation. After many such disappointments, however, it now appears unlikely that we will make a firm connection between protein synthesis and learning merely by pursuing the approaches of the past. Our experience with drugs has shown that all the amnestic agents often interfere with memory in ways that seem unrelated to their inhibition of protein synthesis, More importantly, the notion that the interruption or intensification of protein production in the brain can be related in cause-and-effect fashion to learning now seems simplistic and unproductive. Remove the battery from a car and the car will not go. Drive the car a long distance at high speed and the battery will become more highly charged. Neither of these facts proves that the battery powers the car, only a knowledge of the overall automotive system will reveal its mechanism of locomotion and the role of the battery within that system.
所以,P的作用很令人失望,最红被认为是一个对于失忆学习很不好的材料。虽然,他不好只是对于我们的关于抑制PS来说。虽然有失望,但是我们可能并不能只用过去使用的方法来研究PS和学习的联系了。我们用drug的经历表明所有的失忆要拼都会打扰记忆,而且那些记忆和他们抑制的PS并没有关系。更关键的是,干扰或者加强大脑中蛋白质的生产可能与学习行为有因果关系的想法,现在看来又简单又没用。 拿掉电池,汽车就走不动,长距离高速行驶,电池就会高速充电。这两个试试并没有证明电池是汽车的动力,只有了解汽车的全部系统才能了解汽车运转的机制和电池在这个系统里的作用。
1. This passage was most likely excerpted from
A a diary kept by a practicing neurobehavioral researcher
B a newspaper article on recent advances in the biochemistry of learning
C a technical article on experimental techniques in the field of molecular biology
D an article summarizing a series of scientific investigations in neurobehavioral research
E a book review in a leading journal devoted to genetic research
2.The primary porpoise of the passage is to show that extensive experimentation has
A demonstrated the importance of amino- acid fragmentation in the induction of amnesia
B cast doubt on the value of puromycin in the neurobehavioral investigation of learning
C revealed the importance of amnesia in the neurobehavioral study of learning
D not yet demonstrated the applicability of molecular biology to neurobehavioral research
E not supported the hypothesis that learning is directly dependent on protein synthesis
之前那些研究全都是用来证明最后一句的
定位: Our experience with drugs has shown that all the amnestic agents often interfere with memory in ways that seem unrelated to their inhibition of protein synthesis, More importantly, the notion that the interruption or intensification of protein production in the brain can be related in cause-and-effect fashion to learning now seems simplistic and unproductive. Remove the battery from a car and the car will not go. Drive the car a long distance at high speed and the battery will become more highly charged. Neither of these facts proves that the battery powers the car, only a knowledge of the overall automotive system will reveal its mechanism of locomotion and the role of the battery within that system.
3.According to the passage, neurobehaviorists initially based their that protein synthesis was related to learning on which of the following?
A Traditional theories about learning
B New techniques in protein synthesis
C Previous discoveries in molecular biology
D Specific research into learning and amnesia
E Historic experiments on the effects of puromycin
定位: The conceptual framework for this research was derived directly from molecular biology,
4.The passage mentions all of the following as effects of puromycin EXCEPT
A brain seizures
B memory loss
C inhibition of protein synthesis
D destruction of genetic information
E fragmentation of amino-acid chains
5. It can be inferred from the passage that, after puromycin was perceived to be a disappointment, researchers did which of the following?
A They ceased to experiment with puromycin, and shifted to other promising protein-synthesis inhibitions.
B They ceased to experiment with puromycin, and reexamined through experiments the relationship between genetic information and acquired information.
C They continued to experiment with puromycin, but applied their results to other facets of memory research.
D They continued to experiment with puromycin, but also tried other protein-synthesis inhibitors.
E They continued to experiment with purpomycin until a new neuroanatomical framework was developed.
定位:
In our frustration, our initial response was simply to change drugs rather than cur conceptual orientation.
A 停止用P实验,改用其他的PS抑制方法
6. In the example of the car (lines 73-82), the battery is meant to represent which of the following elements in the neurobehavioral research program?
A Puromycin
B Amnesia
C Glutarimides
D Protein synthesis
E Acquired information
定位:the notion that the interruption or intensification of protein production in the brain can be related in cause-and-effect fashion to learning now seems simplistic and unproductive. Remove the battery from a car and the car will not go. Drive the car a long distance at high speed and the battery will become more highly charged. Neither of these facts proves that the battery powers the car, only a knowledge of the overall automotive system will reveal its mechanism of locomotion and the role of the battery within that system.
前一句说:蛋白质生成和学习的因果关系
后面举例,电池和汽车虽然有联系,但是不代表他们两个的联系是直接联系,那么battery就是在说蛋白质。
7. Which of the following statements would be most likely to come alter the last sentence of the passage?
A The failures of the past, however, must not impede further research into the amnestic action of protein-synthesis inhibitors
B It is a legacy of this research, therefore, that molecular biology's genetic models have led to disagreements among neuro-behaviorists.
C The ambivalent status of current research, however, should not deter neurobe-haviorists from exploring the deeper connections between protein production and learning.
D It is important in the future,therefore,for behavioral biochemists to emphasize more strongly the place of their specific finding within the overall protein synthe-sis model of learning.
E It is important in the future, therefore, for behavioral biochemists to focus on the several components of the total learning system.
改变最后一句话的目的。
最后一句话再说,虽然有关联,但不一定是直接关联,要研究整体才行
A 以前的失败不能阻止以后的研究,指的是失忆和P抑制
B MB以为这个研究不同意NB
C 这个研究太模糊,但是不能阻止NB对于PP和L的根深研究
D未来BC要强调他们的结果和PS与L
E未来BC要集中研究L系统的组成部分
E刚好和最后一句相反,最后一句说要研究整体,E说要研究部分
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