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pingko
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发表于 2011-1-11 18:09:07 |显示全部楼层

http://www.ncbi.nlm.nih.gov/pubmed/20653096

谁能帮我试一下能下这篇综述不。。。
在NATURE的网站上是要收费的 http://www.nature.com/nrneurol/journal/v6/n7/full/nrneurol.2010.80.html

在国外的童鞋看看能找到其他免费下的地方不

谢谢

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capric
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发表于 2011-1-11 19:57:17 |显示全部楼层

本帖最后由 capric 于 2011-1-11 20:01 编辑

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Neurology. 2010 May 11;74(19):1524-30.

Occupational exposure to pesticides increases the risk of incident AD: the Cache County study.
Hayden KM, Norton MC, Darcey D, Ostbye T, Zandi PP, Breitner JC, Welsh-Bohmer KA; Cache County Study Investigators.

Duke University Medical Center, Durham, NC, USA. khayden@duke.edu

Comment in:

Nat Rev Neurol. 2010 Jul;6(7):353.

Abstract
BACKGROUND: Commonly used organophosphate and organochlorine pesticides inhibit acetylcholinesterase at synapses in the somatic, autonomic, and central nervous systems and may therefore have lasting effects on the nervous system. Few studies have examined the relationship of pesticide exposure and risk of dementia or Alzheimer disease (AD). We sought to examine the association of occupational pesticide exposure and the risk of incident dementia and AD in later life.

METHODS: Residents of the agricultural community of Cache County, UT, who were aged 65 years and older as of January 1995, were invited to participate in the study. At baseline, participants completed detailed occupational history questionnaires that included information about exposures to various types of pesticides. Cognitive status was assessed at baseline and after 3, 7, and 10 years. Standardized methods were used for detection and diagnosis of dementia and AD. Cox proportional hazards survival analyses were used to evaluate the risk of incident dementia and AD associated with pesticide exposure.

RESULTS: Among 3,084 enrollees without dementia, more men than women reported pesticide exposure (p < 0.0001). Exposed individuals (n = 572) had more years of education (p < 0.01) but did not differ from others in age. Some 500 individuals developed incident dementia, 344 with AD. After adjustment for baseline age, sex, education, APOE epsilon4 status, and baseline Modified Mini-Mental State Examination scores, Cox proportional hazards models showed increased risks among pesticide-exposed individuals for all-cause dementia, with hazard ratio (HR) 1.38 and 95% confidence interval (CI) 1.09-1.76, and for AD (HR 1.42, 95% CI 1.06-1.91). The risk of AD associated with organophosphate exposure (HR 1.53, 95% CI 1.05-2.23) was slightly higher than the risk associated with organochlorines (HR 1.49, 95% CI 0.99-2.24), which was nearly significant.

CONCLUSIONS: Pesticide exposure may increase the risk of dementia and Alzheimer disease in late life.

PMID: 20458069 [PubMed - indexed for MEDLINE]PMCID: PMC2875926 [Available on 2011/5/11]

Publication Types, MeSH Terms, Substances, Grant SupportPublication Types:
Research Support, N.I.H., Extramural
MeSH Terms:
Aged
Aged, 80 and over
Agricultural Workers' Diseases/chemically induced*
Agricultural Workers' Diseases/epidemiology
Alzheimer Disease/chemically induced*
Alzheimer Disease/epidemiology
Apolipoprotein E4/genetics
Brain/drug effects*
Brain/pathology
Brain/physiopathology
DNA Mutational Analysis
Female
Genetic Testing
Genotype
Humans
Incidence
Male
Neuropsychological Tests
Occupational Exposure/adverse effects*
Pesticides/adverse effects*
Proportional Hazards Models
Questionnaires
Risk Assessment
Risk Factors
Sex Distribution
Time
Utah/epidemiology
Substances:
Apolipoprotein E4
Pesticides
Grant Support:
P30-AG 028377/AG/NIA NIH HHS/United States
R01-AG1380/AG/NIA NIH HHS/United States
LinkOut - more resourcesFull Text Sources:
Elsevier Science
HighWire Press
MD Consult
Ovid Technologies, Inc.
Other Literature Sources:
COS Scholar Universe
Medical:
Alzheimer Disease - Genetic Alliance
Pesticides - MedlinePlus Health Information
Occupational Health - MedlinePlus Health Information
Farm Health and Safety - MedlinePlus Health Information
Alzheimer's Disease - MedlinePlus Health Information