还在招的三个PhD positions, University of Delaware, University of Leeds

kitty0208UID: 3308655

今天在mailing list 看到， 我不熟悉这个学校和老师，不过Delaware是个离大城市近的好地方


Two PhD positions are available (starting Fall 2012) in the Department of
Animal and Food Sciences at University of Delaware for enthusiastic and
self-motivated applicants to work on studying transcriptional differences
between birds showing high and low feed efficiency (FE) phenotypes. Feed
costs in broiler chickens production account for up to 70% of the total
production costs. The long-term goal in this project is to understand the
molecular genetic basis of variation in FE phenotype, which will be of
particular importance in characterizing fundamental basis of optimal FE
and in discovering biomarkers or candidate genes for FE.

The successful candidates will utilize state-of-the-art genomics methods
and technologies to construct cDNA libraries for Next-Generation
Sequencing (NGS) in an Illumina Hi-seq 2000 sequencer and will use
advanced statistical and computational methods to analyze NGS data in the
high-performance computing cluster at University of Delaware.

Candidates with background in animal science, biology, genetics or
bioinformatics with solid understanding of statistics and experience in
analyzing large data sets are preferred.

Successful candidates will receive a monthly generous stipend and will
also benefit from 100 percent tuition reduction. Deadline for application
is May 18. Applicants should send a letter of interest; a CV; GRE and
TOEFL scores (if foreign students whose primary language is not English)
and name and contact information of 3 references to Dr. Behnam Abasht
(abasht@UDel.edu).

The University of Delaware is an equal opportunity employer, which
encourages applications from minority group members and women.

--
Behnam Abasht
Assistant Professor, Integrative Food Animal Biology
Department of Animal and Food Sciences, University of Delaware
531 S. College Ave., 035 Townsend Hall, Newark, DE 19716
Phone: 302-831-8876 (office), Fax: 302-831-2822
Email: abasht@UDel.edu

**************************************************************************************************************************


PhD Studentships for 2012 in Viral Diseases of Livestock

Title: The role of AKT activation during Avian Infectious Bronchitis Virus
infections


Supervision:
Principal Supervisor: Dr Mark Fife (IAH)
Co Supervisors: Professor Paul Britton (IAH)

University Supervisor: Dr Julian Hiscox (University of Leeds)

Abstract

Phosphatidylinositol-3-kinase (PI3K/AKT) plays a central role in the
regulation of many cellular processes including proliferation, apoptosis and
the innate immune response.  A plethora of studies on human viral pathogens
has confirmed the importance of AKT signalling on the outcome of viral
infections; however few studies (apart from those on avian influenza A) have
examined the involvement of this system in avian species.  At a cellular
level, AKT facilitates intracellular viral replication not only by promoting
host cell survival, but also by modulating viral entry.  AKT has been shown
as fundamental to disease resistance in poultry; the impact of P13K/AKT
signalling in avian viral diseases merits further investigation to enable a
better understanding of diseases that impact on poultry production.

It is our aim to examine the effect of Avian Infectious Bronchitis Virus
(IBV) on AKT signalling and to determine if subversion of this pathway
supports viral replication differentially in the avian host.  The inbred
chicken lines at IAH have been selectively bred and vast amounts of
phenotypic data have been amassed over the past 30 years regarding
host-pathogen interactions and disease resistance.  Initial assessment of
the impact of IBV on P13K/AKT signalling has confirmed phosphorylation of
AKT post infection in IBV susceptible birds.  Experiments using in vitro and
ex-vivo analysis of infection aim to confirm which viral proteins are
responsible for AKT activation.  We will examine both resistant and
susceptible inbred lines for phenotypic differences in these responses.
Extensive genetic and genomic data available for these inbred lines will
then enable comprehensive analysis of potential underlying genetic
variation responsible for these differences. The presence of a "protective"
allele will increase resistance in poultry flocks, and therefore mitigate
outbreaks of disease.  Transcriptome analysis of IBV and mutant IBV
virus-infected cells will be assessed to determine the downstream effects of
AKT activation.

This project will be funded in collaboration with Biomimetics Health
Industries UK and based at IAH Compton. Students will be registered at the
University of Leeds. It should be noted that the Genetics and Genomics
Group, including this position, may relocate to IAH Pirbright during the
course of the studentship.

Contact mark.fife@iah.ac.uk for further details.

lian_zhuxiUID: 2151209

谢谢分享 还没offer的同学不妨试试看

penny2011UID: 3033256

没人去的项目还敢去？