做最强的自己，与子征战兮路漫长

zhangheng1020UID: 2130513

下午趴青蛙，我躺在床上，一个体重比较轻的朋友坐在我的屁股上，花了半个小时的时间，确实把我整个压下去了~~真的感觉髋关节快要脱臼了~~

前几天的酸痛让我要很久很久才能完全活动开，我晚上一边看电影《冲出亚马逊》来鼓励自己，一边压腿，前后1个多小时。中间练习竖叉的时候朋友尝试把我的前腿扳到他的膝盖高度上，试了几次都不成功，只能尽量抬高我的前腿，然后踩住我的pp。疼啊，他还不停的说，身体趴下去，趴下去~~~我嘴上说“是，知道了”尽量向下趴，可是两个胳膊还是本能的撑着上半身:( 。另一个朋友看见了，从前面拉着我的胳膊，我就又下去了一点:P ......等到最后放下我的腿，我整个人都趴在地上爬不起来.....:mad: :mad:

还好这样的拉伸只做了两次，剩下的时间都是我180度的竖叉交叉压腿。但是欧的汗汗还是干了又湿，湿了又干好几次:loveliness:

zhangheng1020UID: 2130513

http://www.zgxl.net/cptoday/xlsy/dwsybhdw.htm
http://www.imeet.cn/bbs/viewthre ... 3D14&sid=AeDMeG
http://asiapacific.amnesty.org/a ... erials_ACT750012002
http://www.coolfamily.com.tw/yang/paper01.htm

zhangheng1020UID: 2130513

我倒，刚才检索自己的老帖子才看见这一个~~~
https://bbs.gter.net/thread-788105-1-1.html
寒一下~~

zhangheng1020UID: 2130513

我觉得，软体训练，强身是很重要的一方面，但是在 控制身体的过程中，学习将精神和身体更好融合的技巧才是更为宝贵的收获。这样的体验不仅仅在柔术训练中时时的反证和进一步的领悟，在日常生活中，工作和学习中，努力把一件事情做到接近极致的过程中同样非常适用。

http://www.ruanti.org/bbs/thread-34563-1-1.html

阿HUID: 2393714

:funk:

zhangheng1020UID: 2130513

http://www.mtime.com/group/jiong/discussion/161153/

zhangheng1020UID: 2130513

http://www.youtube.com/watch?v=jPSVpo4mzNI

zhangheng1020UID: 2130513

昨天
早晨踢腿，倒立，控腿
中午仰卧起坐，背起
晚上继续15分钟压腿，一共就30分钟。
最后2分钟是让朋友跪在我背上的


今天早晨起来浑身疼~~~疼啊疼
倒立也非常的吃力，踢腿还好
中午的仰卧起坐50个，做到40就死活都夹不住腿上的球了。背起还能撑住，
但是肘击只能坚持20秒的样子，朋友说“刚开始，就做3分钟吧"
我讨价还价，最后是30秒15组~~
我还没有做，估计完成以后可能就只剩下一口气了
晚上还有压腿和背起等着我~~~

疯了！

nkotbUID: 2208953

想问强人一个问题，既要读书做实验又要如此这般锻炼身体，时间是不是很难安排啊？
偶以后也想坚持做运动。大学里面做的太差了。。。:mad

zhangheng1020UID: 2130513

要乖乖的对自己，就能找时间完成。我压腿的时候，一般边压边看书。


今天任务全部完成

最后的压腿朋友没有主动压我，让我自己耗了一共30分钟。他还说我最近很辛苦，明天不用训练了，可以休息一天。

zhangheng1020UID: 2130513

昨天任务完成，最后的压腿我疼得身上的汗湿透再干掉，湿透再干掉。
------因为看见我很疲劳，所以昨天朋友没有主动压我，让我自己耗了一共30分钟。他还说我最近很辛苦，今天不用训练了，可以休息一天。我最后是爬着回到书桌前面的。。。。。。

结果今天早晨爬起来浑身都痛，早晨的训练倒立试了几次都不成功，只好40个俯卧撑代替。中午50个负重仰卧起坐，感觉基本上像是肚子上压着钉板做下来的。

晚上朋友问我要不要继续训练，我说要。他问我"你确定？如果选择了就要坚持到底。"我早晨训练下来觉得体力流失还不是很厉害，肌肉酸痛也是可以忍受的。我就说我确定，结果那个魔鬼竟然真的没有降低难度让我做。还说什么："......你这是压腿么？......动了动了，重新计时......"。做晚上的负重仰卧起坐也是"高度不够，这个不算......90度，控制身体，注意！"

他奶奶的，最后结束的时候，我真的是觉得浑身太"舒服"了，要不然老娘一定好好的打那小子一顿出气~~

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负重仰卧起坐：就是大腿和上身保持90度垂直，小腿和大腿保持90度垂直，两脚踝90度勾起。脚上控制一个6斤的重物，卷腹肌向上，脖子尽量保持直立不弯。虽然6斤不沉，但做到最后真的是"压死骆驼的最后一根稻草"啊。

                 最讨厌的是，今天陪练（一起租房子住的朋友）回来看见我还有精神，就非说我训练偷懒了。他的女朋友（我的室友）证明我没有偷懒，他说我的运动量不够，今晚上负重训练还要加量~

不活了，不活了，不活了......
踢死他，咬死他，砍死他......
浑身疼，浑身疼，浑身疼......
打个滚，打个滚，打个滚......
不练了，不练了，不练了......
我很乖，我很乖，我很乖......
要坚持，要听话，要超越......
看书去，去看书，做题题......

[ 本帖最后由 zhangheng1020 于 2008-2-17 21:52 编辑 ]

zhangheng1020UID: 2130513

今天早晨负重15斤的1小时快走，纽约的冬天早晨下小雨，我穿薄毛衣和单裤，浑身汗水湿透，顺着头发流下来。早晨踢腿150个完成的质量不错。
中午负重仰卧起坐50完成
晚上
趴青蛙45分钟，
下来俯卧撑做到力竭（打字都手抖）
下来卷腹的抬背腿锻炼腹肌200多下吧（本来是要做到力竭的，我做到后来就数不清楚了，忘记了就重新数，做了2小时都不带累的，最后陪练困了，睡觉了，我自己又折腾了几十个就停下来了）

zhengzheng1026UID: 168914

还是没有锻炼身体。。。:funk:

Olfaction Odors are Detected by a Large Family of Odorant Receptor Molecules How do we perceive a variety of odorants with precision? The answer to this question came from a breakthrough using molecular biological approach. A multigene family of molecules called the 7-transmembrane (because 7 parts of the molecule span the lipid bilayer of the plasma membrane) receptors was discovered. These are G-protein-coupled receptors i.e. they activate effector molecules such as adenylyl cyclasethrough a guanine-nucleotide-binding protein (hence the name G-protein). This family G-protein-coupled receptors (GPCRs) codes for about a 1000 genes in mammals (Slides 6 & 7). It has been found that the receptor neurons in the nasal epithelium express only one of the thousand genes. There is no segregation of the receptor neurons expressing a given GPCR. An astonishing fact is that the receptor neurons expressing a given GPCR project to one or two glomeruli in the olfactory bulb. Olfactory Transduction Begins When Odorants Bind to a G- Protein-Coupled Receptor and Activate a Second Messenger System
The first step in the detection of the odor is binding of the odorant to the receptor molecules. To reach the odorant-binding part of the olfactory rector cell, the cilia, the odor molecules have to traverse through the mucus. There is evidence in the literature for the presence of odorant-binding proteins that are believed to facilitate the transport of the odorants through the mucus.

Transduction begins with the binding of the some sites on the odor molecule with a small region of the binding pocket of the olfactory receptor protein, a G-protein-coupled receptor. The receptor activates adenylyl cyclase (AC), which in turn gives rise to increase in cAMP (Slides 8-10). cAMP binds to the intracellular portion of an ion channel (a cyclic-nucleotide-gated [CNG] channel), enabling to conduct Na+ and Ca2+. The activation of CNG generates an action potential, which is propagated to the second order neurons in the olfactory bulb (Slide 9). Studies in which the G protein specific to the olfactory receptor neurons (Golf), adenylyl cyclase and CNG are individually deleted genetically in mice (knockout mice) provide strong evidence that the cAMP pathway is the critical pathway for signal transduction in the olfactory receptor neurons in vertebrates.

In invertebrates, another second messenger system, namely the inositol lipid signaling system which uses inositol 1,4,5-trisphosphate (IP3) as a second messenger, appears to play a role. In this system the G-protein-coupled receptor activates an enzyme called phospholipase C (PLC) which generates IP3 (Slide 11).
Electrophysiological Recordings Provide Further Evidence for cAMP as the Key Molecule in Olfactory Signal Transduction
Patch clamp recordings show that cAMP directly gives rise to a membrane conductance (IBMX is inhibits decay of camp by the enzyme phosphodiesterase and therefore in effect increases the intracellular levels of camp) and that the same odorants that trigger the rise in the cAMP give rise to a similar conductance (Slide 12). In addition, the extent of elevation of cAMP levels is directly proportional to the potency of a given odorant. The olfactory CNG channel is nonselective for cations, and is opened upon the binding of an odorant to the olfactory receptor complex. This opening results in a depolarization of the ciliary membrane that passively spreads to the cell body, where if it is of sufficient magnitude, and action potential will be generated. This depolarizing receptor potential is said to be graded, in that the further depolarized a neuron becomes (generally the result of higher odorant concentrations), the higher the probability that it will fire action potentials (and the greater the number of action potentials).
Olfactory Receptor Neurons Respond to More than a Single Odorant Electrophysiological recordings have revealed that individual olfactory receptor neurons can respond to several different odorants. In invertebrates, distinctions are made between specialist and generalist receptor neurons, reflecting narrow or broad odorant tuning, respectively. In vertebrate species, specialist neurons have not been found. As we’ve seen previously, the broad tuning of vertebrate generalists could be the result of each neuron expressing multiple receptor proteins, or each receptor protein binding multiple odorants (or both). Nonetheless, any given receptor neuron generally codes only within a rather narrow range of concentrations for a given odorant (Slide 13). Recent evidence suggests that there are hundreds of different olfactory receptor type (which can recognize more than a single odorant), or whether these cells have several different receptors is an unanswered question central to understanding how the olfactory system codes smell.
Different olfactory receptor neurons have different response profiles to different odorants, responding well to some, poorly to others and not at all to still others. This profile can be quantitatively defined by the molecular receptive range (MRR) of the neuron (Slide 14). Although far from definitive, increasing evidence suggests that individual olfactory receptor neurons express but a single receptor protein. In contrast to invertebrates, the responses of vertebrate olfactory receptor neurons to a simple stimulus are generally purely excitatory.

Olfactory Adaptation is Likely to be Mediated by Ca2+
As in most other sensory systems, maintained odor stimulation results in a decline in neuronal response. In the olfactory system this adaptation has been strongly linked to intracellular Ca2+ levels. In the absence of Ca2+ adaptation is eliminated, and intracellular Ca2+ levels are strongly correlated with the open probability of the CNG channel. Ca2+ fluxes have been directly visualized upon prolonged odor stimulation.  

zhengzheng1026UID: 168914

今天的事情还是没做完  鄙视自己

明天 继续review  olfaction

preview olfaction2   

manuscription preparation assignment

lead the discussion part in class

lab work: cell cultrure, see the new stem cells, read the protocol

！！！UID: 2349378

原来两个号是twin id