课时学分: 43 Lectures 课程介绍: An introductory survey of cell and developmental biology. The assembly of supramolecular structures; membrane structure and function; the cell surface; cytoplasmic membranes; the cytoskeleton and cell motility; the eukaryotic genome, chromatin, and gene expression; the cell cycle;organellebiogenesis,differentiation, and morphogenesis. 课程安排:
Membrane Structure - Lipids
Membrane Structure - Proteins
Membrane Dynamics
Membrane Transport - Permeases and Channels
Membrane Transport - Nucleocytoplasmic Exchange
Membrane Assembly - Signal Hypothesis
Membrane Assembly - Translocation Machinery
Membrane Vesicular Traffic
Membrane Traffic to the Lysosome
Membrane Traffic - Cholesterol Regulation
Membrane Transport - Action Potential
Membrane Transport - Synaptic Transmission I
Membrane Transport - Synaptic Transmission II
Membrane Fusion
Visualizing the Cytoskeleton
Actin Filament Structure and Dynamics
Actin Binding Proteins
Myosin and Muscle Contraction
Regulation of Actin Dynamics and Cell Movement
Intermediate Filaments (video clip not available)
QUIZ, Microtubule Structure and Dynamics
Fri 3/9 Microtubule Motors and Motility
Nucleus and Chromosome Structure I
Nucleus and Chromosome Structure II
Mitosis I
Mitosis II and Cytokinesis
Meiosis
Catch Up and Review
Cell Communication
Receptors and Signaling
G Protein Coupled Receptors
GPCR Signaling and Second Messengers
Receptor Tyrosine Kinases
Ras-MAP Kinase Signaling
Regulation of Cell Growth
QUIZ, The Cell Cycle
The G1/S Transition
DNA Replication, G2 and Mitosis
Checkpoints
Apoptosis
Oncogenes and Cancer
Tumor Suppressors
Review
配套教材
Text: Alberts et al., fourth edition 2002 Molecular Biology
of the Cell This is one of the most complete up-to-date texts in cell biology. Moreover parts of it are available on line.However, it often gives more detail than is needed in a introductory course and sometimes less. The emphasis in this course is on the material given in lecture and handouts/readers. The text is primarily used as a
reference for you to look things up, both to fill in details that you missed in lecture and fill in an area beyond our notes for your own benefit.