做最强的自己，与子征战兮路漫长

zhangheng1020UID: 2130513

http://en.wikipedia.org/wiki/Hyperviscosity_syndrome
Hyperviscosity syndrome is an increase in the viscosity of the blood. This may be caused by an increase in serum proteins and may be associated with bleeding from mucous membranes, retinopathy, and especially monoclonal gammopathies such as Waldenström macroglobulinemia and in multiple myeloma. An increased viscosity secondary to polycythemia may be associated with organ congestion and decreased capillary perfusion.

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Polycythemia
http://en.wikipedia.org/wiki/Polycythemia
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Polycythemia
Classification & external resources ICD-10 D45., D75.1
ICD-9 238.4, 289.0, 776.4
DiseasesDB 10295
MeSH D011086
Polycythemia is a condition in which there is a net increase in the total number of red blood cells in the body. The overproduction of red blood cells may be due to a primary process in the bone marrow (a so-called myeloproliferative syndrome), or it may be a reaction to chronically low oxygen levels or, rarely, a malignancy.

zhangheng1020UID: 2130513

http://www.iciba.com/diathese/
http://en.wikipedia.org/wiki/Spe ... =diathese&go=Go
http://dict.cn/ime.html

zhangheng1020UID: 2130513

diathese is franch? I can not find it  in Wikipedia,
http://en.wikipedia.org/w/index. ... ese&action=edit

[ 本帖最后由 zhangheng1020 于 2007-8-24 14:15 编辑 ]

zhangheng1020UID: 2130513

Heparin-induced thrombocytopenia
http://en.wikipedia.org/wiki/Heparin-induced_thrombocytopenia

Heparin-induced thrombocytopenia (HIT) with or without thrombosis (HITT) is thrombocytopenia (low platelet counts) due to the administration of heparin. While it is mainly associated with unfractioned heparin (UFH), it can also occur with exposure to low-molecular weight heparin (LMWH), but at significantly lower rates. Despite the low platelet count, it is a thrombotic disorder, with very high rates of thrombosis, in the arteries with or without venous complications. Of note, the rate of DVT (Deep Venous Thrombosis) is roughly 4 times that of arterial thrombosis, and while thrombocytopenia is the most common "event" in HIT, DVT is in fact the most common complication.
HIT typically develops 4-14 days after the administration of heparin. Heparin (UFH) is used in cardiovascular surgery, as prevention or treatment for deep-vein thrombosis and pulmonary embolism and in various other clinical scenarios. LMWH is increasingly used in outpatient prophylaxis regimes.
There are two forms of HIT. Type II HIT is the main adverse effect of heparin use.

Contents[hide] 1 Type I 2 Type II 3 Diagnosis 4 Treatment 5 Reference 6 External links 7 Reference

zhangheng1020UID: 2130513

antiphospholipid antibody syndrome

http://en.wikipedia.org/wiki/Antiphospholipid_syndrome

Antiphospholipid syndrome (or antiphospholipid antibody syndrome) (APS) is a disorder of coagulation, which causes blood clots (thrombosis) in both arteries and veins, as well as pregnancy-related complications such as miscarriage, preterm delivery, or severe preeclampsia. The syndrome occurs due to the autoimmune production of antiphospholipid antibodies (aPL). The name Antiphospholipid Syndrome is a misnomer because the target antigen of aPL is not phospholipids but actually plasma proteins that bind to phospholipids (eg: β2-glycoprotein 1 or prothrombin).
Antiphospholipid Syndrome is sometimes referred to as Hughes syndrome after the rheumatologist Dr. Graham R.V. Hughes (St. Thomas' Hospital, London, UK) who worked at the Louise Coote Lupus Unit at St Thomas' Hospital in London.
The term "Primary Antiphospholipid Syndrome" is used when APS occurs in the absence of any other autoimmune disease. APS is commonly seen in conjunction with other autoimmune diseases; the term "Secondary Antiphospholipid Syndrome" is used when APS coexists with other autoimmune diseases such as systemic lupus erythematosus (SLE). A very rare form of APS is the Catastrophic Antiphospholipid Syndrome, in which there is multiple and rapid organ thrombosis/dysfunction. Catastrophic APS has a high mortality rate.

Signs and symptoms
The presence of antiphospholipid antibodies (aPL) in the absence of blood clots or pregnancy-related complications does not indicate APS (see below for the diagnosis of APS).

Antiphosphilipid syndrome can cause (arterial/venous) blood clots (in any organ system) or pregnancy-related complications (especially miscarriage in the second or third trimester). In APS patients, the most common venous event is deep vein thrombosis of the lower extremities (blood clot of the deep veins of the legs) and the most common arterial event is stroke.

Other common findings, although not part of the APS Classification Criteria, are thrombocytopenia (low platelet count), heart valve disease, and livedo reticularis (a skin condition). Some patients report headaches and migraines. Antiphospholipid Syndrome can rarely mimic Multiple Sclerosis with an estimated 10% of patients misdiagnosed.

Very few patients with Primary APS go on to develop SLE.

Pathogenesis
Antiphospholipid syndrome is an autoimmune disease, in which "antiphospholipid antibodies" (Anticardiolipin antibodies and Lupus anticoagulant)react against anionic phospholipids on cell membranes. Being an autoimmune disease, it is more common in women than in men. The exact cause is not known, but activation of the system of coagulation is evident. Clinically important antiphospholipid antibodies (those that arise as a result of the autoimmune process) are associated with thrombosis and vascular disease. The syndrome can be divided into primary (no underlying disease state) and secondary (in association with an underlying disease state) forms. The main target of anticardiolipin antibodies is [[β2Glycoprotein 1]] and the main target of Lupus anticoagulant is prothrombin.
The Lupus anticoagulant antibodies are those that show the closest association with thrombosis, those that target β2glycoprotein 1 have a greater association with thrombosis than those that target prothrombin. Anticardiolipin antibodies are associated with thrombosis at moderate to high titres (>40 GPLU or MPLU). Patients with both  Lupus anticoagulant antibodies and moderate/high titre anticardiolipin antibodies show a greater risk of thrombosis than with one alone.
[edit] Laboratory TestsAntiphospholipid syndrome is tested for in the laboratory using both liquid phase coagulation assays (Lupus Anticoagulant Test) and solid phase ELISA assays(Anticardiolipin Antibodies).
Genetic Thrombophilia is part of the differential diagnosis of APS and can coexist in some APS patients. Thus genetic thrombophilia screening can consist of:

• Further studies for Factor V Leiden variant and the prothrombin mutation, Factor VIII levels, MTHFR mutation.
• Levels of protein C, free and total protein S, Factor VIII, antithrombin, plasminogen, tissue plasminogen activator (TPA) and plasminogen activator inhibitor-1 (PAI-1)

The testing of antibodies to the possible individual targets of aPL such as [[β2Glycoprotein 1]] and antiphosphatidyl serine is currently under debate as testing for anticardiolipin appears to be currently sensitive and specific for diagnosis of APS even though cardiolipin is not considered an invivo target for antiphospholipid antibodies.
[edit] Laboratory Tests: Lupus Anticoagulant TestThis is tested for by using a minimum of two coagulation tests that are phospholipid sensitive this is due to the heterogeneous nature of the lupus anticoagulant antibodies. The patient on initial screening will typically have been found to have a prolonged APTT that does not correct in an 80:20 mixture with normal human plasma (50:50 mixes with normal plasma are insensitive to all but the highest antibody levels). The APTT (plus 80:20 mix), dilute Russell's viper venom time (DRVVT), the kaolin clotting time (KCT), dilute thromboplastin time {TDT/DTT) or Prothrombin time (using a lupus sensitive thromboplastin) are the principal tests used for the detection of lupus anticoagulant. These tests must be carried out on a minimum of two occasions at least 6 weeks apart and be positive on each occasion demonstrating persistent positivity to allow a diagnosis of antiphospholipid syndrome. This is to prevent patients with transient positive tests (due to infection etc) being diagnosed as positive.
Distinguishing a lupus antibody from a specific coagulation factor inhibitor (eg: Factor VIII). This is normally achieved by differentiating the effects of a lupus anticoagulant on factor assays from the effects of a specific coagulation factor antibody. The lupus anticoagulant will inhibit all the contact activation pathway antibodies (Factor VIII, Factor IX, Factor XI and Factor XII). Lupus anticoagulant will also rarely cause a factor assay to give a result lower than 35 iudl (35%) where as a specific factor antibody will rarely give a result higher than 10iudl (10%). Monitoring IV anticoagulant therapy by the APTR is compromised due to the effects of the lupus anticoagulant and in these situations is generally best performed using a chromogenic assay based on the inhibition of Factor Xa by Antithrombin in the presence of Heparin.
[edit] Laboratory Tests: Anticardiolipin AntibodiesThese can be detected using an enzyme-linked immunosorbent assay (ELISA) immunological test, which screens for the presence of β2glycoprotein 1 dependent anticardiolipin antibodies (ACA).
A Low platelet count and positivity for antibodies against [[β2-glycoprotein]] or phosphatidylserine may also be observed in a positive diagnosis.

[ 本帖最后由 zhangheng1020 于 2007-8-24 15:16 编辑 ]

zhangheng1020UID: 2130513

unfractionated heparin   指的是普通的肝素么？特别是后文有小分子肝素 low-molecular weight heparin (LMWH). it is in HIT Heparin-induced thrombocytopenia.
Heparin-induced thrombocytopenia (HIT) with or without thrombosis (HITT) is thrombocytopenia (low platelet counts) due to the administration of heparin. While it is mainly associated with unfractioned heparin (UFH)

[ 本帖最后由 zhangheng1020 于 2007-8-24 15:50 编辑 ]

zhangheng1020UID: 2130513

Eat too much leeeeeeeeeerrer
1 pizza 1/6  
2 vegetable salads 1 cup
3 fat free milk 1 cup
4 100% wheatmeal biscuits 5 pieces

zhangheng1020UID: 2130513

unfractionated heparin 简写是UFH，可以翻译成未分级肝素。有些研究认为它是小分子肝素的一种比较好的替代品。

moondy74178945UID: 2231844

do u plan how to spend ur weekend?

zhangheng1020UID: 2130513

weekend?weekend?weekend?weekend?
no wonder the library closed so early...:(

guesswhatUID: 2231211

原帖由 zhangheng1020 于 2007-8-26 10:37 发表
weekend?weekend?weekend?weekend?
no wonder the library closed so early...:(

How inconsiderate! There're too many students who have to work 24/7 to pass those exams.

67169619UID: 2320695

lei a

guesswhatUID: 2231211

clinical obese/clinical depression

zhangheng1020UID: 2130513

yep,tired...:(
but I will keep my words!:mad :mad